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KMID : 1100220090080010067
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Dementia and Neurocognitive Disorders
2009 Volume.8 No. 1 p.67 ~ p.73
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Freezing of gait and cognitive functions in patients with Parkinson’s disease
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Chung Sun-Ju
Park Hee-Kyung
Lee Sook-Joung
Kim Seong-Ryeol
Kim Mi-Jung
Kwon Mi-Seon
Lee Jae-Hong
Lee Myoung-Chong
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Abstract
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Background: Freezing of gait (FOG) in Parkinson’s disease (PD) is a unique motor symptom, representing the breakdown of essential components of gait. We aimed to study the correlation between FOG and cognitive functions, particularly focusing on frontal and parietal functions, in patients with PD.
Methods: We prospectively studied 25 patients with PD, including 15 PD patients with freezing (PDF) and 10 PD patients without freezing (PDNF). Gait analysis was performed with 3-dimensional gait analysis system that includes six cameras. The frequency of freezing episodes per one cycle, total step numbers per one cycle, and total time of one gait cycle were evaluated. All patients were evaluated with K-MMSE, Montreal Cognitive Assessment-Korean (MoCA-K), and Rey Complex Figure Test (RCFT).
Results: In PDF, there was significant improvement in total step number, total time, gait velocity, cadence, and stride length after using visual cue. For auditory cue, in PDF, there was significant improvement in total step number, total time, freezing number, and cadence. FOG in PD was associated with some aspects of frontal dysfunction. However, there was no significant correlation between gait features and other cognitive tests, including total scores of K-MMSE, MoCA-K, and RCFT, in both PDF and PDNF.
Conclusion: FOG in PD was significantly improved by external cues. FOG in PD was associated with some aspects of frontal dysfunction, which warrants for further investigations in detail.
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KEYWORD
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Freezing of gait, Parkinson’s disease, Cognitive function, Gait analysis
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